Comfortis Plus – A Detailed Review – Facts, Benefits & Precautions

By Alberto Roy

Updated on:

Comfortis Plus is a monthly chewable tablet that controls fleas, intestinal worms and heartworms. Comfortis is a good product to get all-around protection from fleas for your dog. Comfortis Plus is a perfect fit to eliminate fleas as well as intestinal worms from your pet and to protect them from heartworms.

If you find that a product starts killing fleas within 30 minutes and relieves your dog from flea itchiness and scratching, then nobody is much relaxed and stress free than you.

Comfortis Plus As Dog Flea Control, Tick & Worming Treatment

This scenario is true for every pet parent. Seeing a pet in a notion of distress with that constant scratching and gnawing definitely will leave you pissed off or frustrated. No wonder you would be looking for a remedy that can instantly provides relief from fleabites.

Fortunately, one such advanced and innovative flea treatment comes handy with an added advantage of heartworm prevention and worm treatment – COMFORTIS PLUS.

Protects Dogs From Fleas, Worms and Heartworm

Comfortis PLUS for Dogs are the tasty, convenient way to protect your dog against heartworm and common intestinal worms, and kill fleas rapidly and keep them off for an entire month!

Major Benefits of Comfortis Plus 

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Starts Working Instantly

The oral flea treatment has a quick mechanism to work fast and attack the fleas. It takes as little as 30 minutes to start killing fleas and thus provides instant relief from those itchy fleabites.

Prevents Heartworm Disease

With an efficacy of eliminating the immature forms of heartworms, Comfortis Plus easily controls heartworm disease in dogs.

Treats Intestinal Worms

Loaded with exceptional ingredient, the oral chew is capable of treating and eliminating intestinal worms in dogs. It acts on the intestinal worm infection and further protects dogs against future infestation.

Highly Palatable 

Comfortis Plus is available in a convenient beef flavored chewable tablet. The flavor makes it highly palatable and readily accepted by your furry pals.

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Maximum Effectiveness

The oral chew is proven to have maximum effectiveness when it is mixed with food. Therefore, it is efficient and easy to mix with food.

Safe for Puppies

Tested under various conditions on dogs and puppies, it is proven that Comfortis Plus is safe to use for puppies from 8 weeks of age.

Broad Spectrum Protection

Comfortis Plus is a potent broad-spectrum treatment providing wide range of benefits. The oral treatment is not only effective in destroying fleas but also controls future infestations.

It aids in the treatment strategy of flea allergy dermatitis. Loaded with key ingredients, the chew has the efficacy of eliminating intestinal worms including roundworms, hookworms and whipworms.

This advanced version of Comfortis by Elanco is especially developed to provide the added protection to dogs against heartworm disease.

Comfortis PLUS for Dogs Heartworm, Flea and Worming Summary

Comfortis Plus for Dogs

Comfortis PLUS (formerly Panoramis) Chewable Heartworm, Flea and Intestinal Worm Tablets for Dogs are the tasty, meat flavoured way to protect your dog against heartworm and common intestinal worms, as well as rapidly kill fleas and prevent flea infestations for a full month.

Comfortis PLUS combines two trusted and effective active ingredients (spinosad + milbemycin oxime) to provide broad spectrum parasite control.

Comfortis PLUS is the only chewable tablet with will kill fleas for an entire month at the same time as protecting against heartworm, hookworm, roundworm, and whipworm.

No more messy or sticky spot-on treatments, which leave a chemical residue on your pet and you. Now your best friend is more huggable than ever!

If you best friend loves the water, the Comfortis PLUS for Dogs is for them. Unlike most broad spectrum products on the market, the effectiveness of Comfortis PLUS tablets is not reduced by swimming or bathing. No more reapplying the flea control before the month is over.

The anti-flea active ingredient in Comfortis PLUS (spinosad) is a new and unique ingredient, which is recommended in cases where there has been demonstrated flea resistance to existing, older flea treatments.

If your dog’s current flea control treatment has stopped working, we recommend that you give Comfortis PLUS a try!

Major Facts about Comfortis Plus You Will Never Know

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Due to the active ingredient Spinosad in Comfortis Plus – received a Presidential Green Chemistry Challenge Award from the U.S. Environmental Protection Agency. It indicates that spinosad as a technology for insect control has a favorable environmental benefit to Comfortis Plus.

The oral chew has become a valuable tool in the fight against fleas, worms and heartworms, particularly in the flea-endemic regions.

General Guidelines for Administering Comfortis Plus

Top 4 Reasons to Use Comfortis over a Spot-on

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Top 4 reasons to use Comfortis vs a spot-on product such as Frontline Plus, Advantage, or Advantix:

  1. Convenience : The beef-flavored chewable tablets means that dosing is easy! No more messy residue everywhere or chasing the dog around the house to apply a liquid.
  2. Water-fast : Comfortis is not a spot-on, so there is no liquid to wash off. Great for dogs who love the water!
  3. Fast acting : No more waiting 24-48 hours for the fleas to disappear – Comfortis starts killing fleas within 30 minutes, with 100% of fleas killed within only 4 hours.
  4. No resistance problems : Due to its unique mode of action, Comfortis does not have the flea resistance problems experienced by the older, topical flea treatments such as Frontline Plus, Advantage, and Advantix. In households where these ‘spot-ons’ are no longer effective or have reduced efficacy, we recommend that you try Comfortis.

Solve your flea problem now and start to benefit from the advanced flea fighting technology in Comfortis.

Comfortis PLUS for Dogs FAQs

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The following are some Frequently Asked Questions (FAQs) about Comfortis PLUS for Dogs. If you have a different question concerning this product, please contact us.

I have a new puppy. When can I start Comfortis PLUS ?

Comfortis PLUS for Dogs is safe to use in puppies from 8 weeks of age. We recommend starting at 14 weeks however as some younger puppies may get an upset stomach.

My dog loves the water and/or needs lots of baths. How do I protect him against fleas and other parasites?

Comfortis PLUS has a unique mode of action, which means that the effectiveness of the product is not reduced no matter how many times your dog goes swimming or has a bath. Comfortis PLUS is perfect for water loving dogs.

What worms does Comfortis PLUS protect against?

Comfortis PLUS protects your dog against heartworm, hookworm, roundworm and whipworm. It is 99.8% effective against the most common canine intestinal worm seen in veterinary clinics and kennels.

To give your dog protection against tapeworm, combine Comfortis PLUS with a tapewormer or general all wormer every 3 months.

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Can I use Comfortis PLUS for my cat?

No. Comfortis PLUS cannot be given to cats as the safety and efficacy has not be tested in that species. At present there is not a Comfortis PLUS for Cats.

Precautionary Measures That Should Never be Neglected

With myriad features, Comfortis Plus no doubt is an exceptionally effective multi spectra treatment.

Pricing of Comfortis Plus

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Comfortis Plus is not only effective but also affordable. When you look forward to buy three different treatments for three conditions, it would definitely end up too costly.

However, with Comfortis Plus – a broad-spectrum treatment – controlling multiple parasites – fleas, heartworms, intestinal worms including roundworms, hookworms and whipworms, it turns out to be much cheaper.

Comfortis Plus when compared to other treatments is highly affordable. So, why to spend more when you save extra.

Valuable Information About Comfortis Plus

Refrigerated Product :   No

Parasites Controlled :    Fleas, Heartworm, Intestinal Worms

Dose Form  :       Tablet / Oral

Duration of Effect :         4 weeks

Indication   :       Monthly administration for prevention of heartworm disease (Dirofilaria immitis) ; treatment, prevention and control of flea infestations (Ctenocephalides felis) and control of flea allergy dermatitis; treatment and control of adult hookworm (Ancylostoma caninum), roundworm (Toxocara canis and Toxascaris leonina) and whipworm (Trichuris vulpis) infections in dogs and puppies from 8 weeks of age, and ≥ 2.3 kg bodyweight.Spinosad has been demonstrated to rapidly kill fleas; studies confirmed that spinosad began to kill fleas within 30 minutes and was 100% effective within four hours.

There are no restrictions on swimming or washing after treatment with Panoramis, so the dog can be treated while wet and exposed to water immediately after treatment.

There is no requirement to exclude the dog from access to any furniture or home fittings. The product is not a topical one, therefore cannot damage any surfaces or other materials in the home.

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Actions : Spinosad is a member of the spinosyn class of insecticides and has a unique action on the insect nervous system, causing nerve excitation, leading to muscle contractions, paralysis and death in fleas. Milbemycin oxime is a member of the macrocyclic lactone class of anthelmintics.

It increases nematode membrane permeability to chloride ions via glutamate gated chloride ion channels, leading to flaccid paralysis and death of target parasites. Milbemycin oxime prevents heartworm and controls gastrointestinal nematodes.

Precautions  :    Comfortis Plus (Panoramis) should not be administered to puppies less than 8 weeks of age. Puppies less than 14 weeks of age may experience an increased rate of vomiting.

Seek veterinary advice regarding the use of Panoramis in pregnant and lactating females and dogs with pre-existing epilepsy. The safe use of Panoramis in breeding males has not been evaluated.

Concurrent use of Panoramis with high extralabel doses of ivermectin for parasitic mange or demodicosis may be associated with an increased risk of neurological signs typically associated with ivermectin toxicity.

Panoramis should not be administered concurrently with extralabel high doses of macrocyclic lactones.The use of Panoramis in dogs suffering from microfilaraemia is not recommended.

On rare occasions, transient shock-like (hypersensitivity) reactions have been observed in heartworm positive animals carrying a high number of microfilariae at the time of the first treatment with milbemycin oxime.

Dogs with an existing adult D. immitis heartworm infection should be treated with an adulticide prior to commencement of Panoramis.First Aid If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131 126.

Dosage and Administration  :    

Comfortis Plus (Panoramis) tablets are given orally, once a month. The recommended minimum dose is spinosad 30 mg/kg bodyweight and milbemycin oxime 0.5 mg/kg.Recommended dose.

Dogs 2.3 to 4.5 kg bodyweight. 1 tablet (spinosad 140 mg, milbemycin oxime 2.3 mg). 4.6 to 9 kg. 1 tablet (spinosad 270 mg, milbemycin oxime 4.5 mg). 9.1 to 18 kg. 1 tablet (spinosad 560 mg, milbemycin oxime 9.3 mg). 18.1 to 27 kg. 1 tablet (spinosad 810 mg, milbemycin oxime 13.5 mg). 27.1 to 54 kg. 1 tablet (spinosad 1620 mg, milbemycin oxime 27 mg). > 54 kg.

Administer the appropriate combination of tablets.Administer with food for maximum effectiveness; may be consumed as a treat just prior to feeding, offered in food or in conjunction with a meal.

To ensure that the entire dose is consumed, watch the dog for several minutes following tablet administration.

If the full dose is not consumed, redose as soon as possible with the full dose.Panoramis should be administered at monthly intervals, preferably on the same date each month.

If a dose is missed and the monthly interval between doses is exceeded by less than 14 days, immediate administration of Panoramis with food and resumption of a monthly dosing schedule will minimise the opportunity for the development of adult heartworms, intestinal worms and reinfestation by fleas.

Treatment may begin at any time of the year, preferably starting one month before fleas and/or mosquitoes become active and continuing monthly to the end of flea and mosquito season.

In areas where fleas or mosquitoes are common year round, monthly treatment with Panoramis should continue the entire year without interruption.

When replacing another monthly heartworm preventive product, the first dose of Panoramis must be given within one month of the last dose of the previous monthly medication.

Storage  :

Store below 25°C (air conditioning) and protect from light. Store the unused product in the original closed container.

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